XBP1

XBP1
المعرفات
الأسماء المستعارة	XBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 194355 MGI: MGI:98970 HomoloGene: 3722 GeneCards: 7494
علم الوجود الجيني
الوظيفة الجزيئية	• estrogen receptor binding; • protein homodimerization activity; • RNA polymerase II transcription factor binding; • protease binding; • ‏GO:0001948 ربط بروتيني; • protein kinase binding; • sequence-specific DNA binding; • ‏GO:0001158 core promoter proximal region sequence-specific DNA binding; • protein heterodimerization activity; • chromatin DNA binding; • ubiquitin protein ligase binding; • ربط دي إن إي; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • RNA polymerase II regulatory region sequence-specific DNA binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • identical protein binding;
المكونات الخلوية	• عصارة خلوية; • غشاء; • مكون تكاملي للغشاء; • بلازم نووي; • integral component of endoplasmic reticulum membrane; • endoplasmic reticulum membrane; • سيتوبلازم; • شبكة إندوبلازمية; • نواة;
العمليات الحيوية	• positive regulation of MHC class II biosynthetic process; • positive regulation of protein phosphorylation; • negative regulation of endoplasmic reticulum unfolded protein response; • positive regulation of immunoglobulin production; • muscle organ development; • vascular endothelial growth factor receptor signaling pathway; • phosphatidylinositol 3-kinase signaling; • استماتة; • ضبط نسخ الدنا; • regulation of protein stability; • glucose homeostasis; • نسخ الدنا; • تكاثر الخلايا; • positive regulation of endothelial cell apoptotic process; • response to unfolded protein; • fatty acid biosynthetic process; • protein transport; • positive regulation of TOR signaling; • exocrine pancreas development; • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • تمايز خلوي; • positive regulation of autophagy; • cellular response to laminar fluid shear stress; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • positive regulation of B cell differentiation; • negative regulation of transcription from RNA polymerase II promoter; • cellular response to fluid shear stress; • organelle organization; • regulation of autophagy; • استجابة مناعة; • positive regulation of proteasomal protein catabolic process; • positive regulation of plasma cell differentiation; • positive regulation of T cell differentiation; • positive regulation of endoplasmic reticulum unfolded protein response; • positive regulation of histone methylation; • أيض الليبيدات; • epithelial cell maturation involved in salivary gland development; • positive regulation of protein acetylation; • positive regulation of ER-associated ubiquitin-dependent protein catabolic process; • التهام ذاتي; • نمو متعدد الخلايا; • ATF6-mediated unfolded protein response; • IRE1-mediated unfolded protein response; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • epithelial cell maturation; • cellular response to oxidative stress; • cellular response to vascular endothelial growth factor stimulus; • protein destabilization; • cellular response to peptide hormone stimulus; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • negative regulation of pathway-restricted SMAD protein phosphorylation; • adipose tissue development; • positive regulation of vascular associated smooth muscle cell migration; • liver development; • cellular triglyceride homeostasis; • cholesterol homeostasis; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of lactation; • cellular response to amino acid stimulus; • توليد الأوعية; • cellular response to glucose starvation; • response to insulin-like growth factor stimulus; • negative regulation of ERK1 and ERK2 cascade; • fatty acid homeostasis; • positive regulation of vascular smooth muscle cell proliferation; • positive regulation of hepatocyte proliferation; • sterol homeostasis; • cellular response to interleukin-4; • positive regulation of protein kinase B signaling; • ubiquitin-dependent protein catabolic process; • positive regulation of fat cell differentiation; • negative regulation of apoptotic process; • endothelial cell proliferation; • transcription from RNA polymerase II promoter; • ضبط زيادي للتكاثر الخلوي; • negative regulation of myotube differentiation; • positive regulation of cell migration; • استجابة البروتين غير المطوي; • cellular response to nutrient; • cellular response to insulin stimulus; • response to endoplasmic reticulum stress; • positive regulation of vascular wound healing; • positive regulation of angiogenesis; • neuron development; • positive regulation of immunoglobulin secretion; • cellular response to lipopolysaccharide; • cellular response to fructose stimulus; • cellular response to glucose stimulus; • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; • cellular response to leukemia inhibitory factor; • positive regulation of protein import into nucleus; • regulation of cell growth;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P17861
	O35426
	‏NM_001079539 NM_005080، ‏NM_001079539
	‏NM_013842 NM_001271730، ‏NM_013842
	‏NP_005071 NP_001073007، ‏NP_005071
	‏NP_038870 NP_001258659، ‏NP_038870
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

البروتين 1 المرتبط بالصندوق-X (بالإنجليزية: X-box binding protein 1)‏ ويُعرف كذلك بـ XBP1 هو بروتين يُشفر لدى البشر بواسطة الجين XBP1. يتواجد الجين XBP1 في الصبغي 22 بينما تم التعرف على جين كاذب قريب الصلة به ويتواجد في الصبغي 5. البروتين XBP1 عامل نسخ ينظم التعبير الجيني وهو مهم للعمل السليم للنظام المناعي ولاستجابة الإجهاد الخلوي.

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